ADME Complete PK Profiling
40% Drug Failures from PK
CYP450 Metabolism Prediction
FDA 3.0 Human-Relevant Models
Multi-Organ Linked Systems
PBPK Model Validation
DDI Drug-Drug Interactions
$1.5B OOC Market by 2030
ADME Complete PK Profiling
40% Drug Failures from PK
CYP450 Metabolism Prediction
FDA 3.0 Human-Relevant Models
Multi-Organ Linked Systems
PBPK Model Validation
DDI Drug-Drug Interactions
$1.5B OOC Market by 2030
Complete Pharmacokinetic Platform

The Drug's
Full Journey.

Integrated organ-on-chip system modeling absorption, distribution, metabolism, and excretion. Human pharmacokinetics before first-in-human trials.

A GUT D PLASMA M LIVER E KIDNEY DRUG IN CLEAR OUT CONCENTRATION vs TIME Cmax t1/2 ABSORPTION DISTRIBUTION METABOLISM EXCRETION
40%
Failures from Poor PK
4
Integrated Organ Systems
85%
IVIVE Correlation
10x
Faster Than Animal PK

Complete ADME Profiling

Every stage of drug pharmacokinetics on a single integrated platform.

A

Absorption

Intestinal permeability, efflux transporters, first-pass gut metabolism

Gut-on-Chip
D

Distribution

Plasma protein binding, tissue distribution, BBB penetration

Multi-Organ
M

Metabolism

CYP450 profiling, metabolite ID, enzyme induction/inhibition

Liver-on-Chip
E

Excretion

Renal clearance, biliary excretion, transporter-mediated elimination

Kidney-on-Chip

Integrated Organ Systems

Physiologically connected tissue compartments for systemic drug behavior.

?? Liver Metabolism
  • CYP1A2, 2C9, 2C19, 2D6, 3A4
  • Phase I/II metabolism
  • Metabolite identification
  • Drug-drug interactions
?? Intestine Absorption
  • Papp permeability
  • P-gp efflux ratio
  • Gut metabolism (CYP3A4)
  • Food effects
?? Kidney Excretion
  • GFR / tubular secretion
  • OAT/OCT transporters
  • Renal clearance prediction
  • Nephrotoxicity markers
?? Brain CNS Distribution
  • BBB permeability
  • P-gp/BCRP efflux
  • Brain:plasma ratio
  • CSF penetration
?? Lung Pulmonary
  • Inhaled drug deposition
  • Alveolar absorption
  • Pulmonary metabolism
  • Local vs systemic
?? Blood Distribution
  • Plasma protein binding
  • Blood:plasma ratio
  • RBC partitioning
  • Circulating metabolites

Industry Leaders

Organizations advancing multi-organ ADME platforms.

CN Bio Multi-Organ
PhysioMimix linked gut-liver-kidney for systemic ADME
TissUse HUMIMIC
4-organ ADME chip with physiological fluid flow
Emulate Linked Chips
Modular organ-chip linking for PK studies
Hesperos Human-on-Chip
Serum-free multi-organ with recirculating media
Mimetas OrganoPlate
High-throughput ADME in 384-well format
Organovo 3D Bioprint
Bioprinted liver tissues for metabolism studies

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